Unusual in Water Multicomponent Reaction of 3-Amino-5-methylpyrazole, Acetylacetone and Aldehyde

Irina Tkachenko, Sergey Komykhov, Vladimir Musatov, Valentyn Chebanov, Sergey Desenko

Abstract

Multicomponent reaction of 3-amino-5-methylpyrazole, aliphatic aldehyde (paraformaldehyde or acetaldehyde) and acetylacetone in water by conventional heating, microwave or ultrasound activation undergoes on molar amounts of reagents 2:1:2, respectively, leads bis(2,5,7-trimethylpyrazolo[1,5-a]pyrimidin-6-yl)-substituted methane or to corresponding 1,1-bis-substituted ethane.

Keywords

multicomponent reactions; heterocycles; 3-aminopyrazole derivative; in water synthesis; microwave-assisted synthesis; ultrasonication

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DOI

https://doi.org/10.17721/fujcV7I1P90-95

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