Unusual in Water Multicomponent Reaction of 3-Amino-5-methylpyrazole, Acetylacetone and Aldehyde

Authors

  • Irina Tkachenko Kharkiv Scientific Research Forensic Center, Ministry of Internal Affairs of Ukraine, Kovtuna str., 32, Kharkiv 61036 Ukraine
  • Sergey Komykhov State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Nauky Ave 60, Kharkiv 61072 Ukraine http://orcid.org/0000-0002-4674-4115
  • Vladimir Musatov State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Nauky Ave 60, Kharkiv 61072 Ukraine
  • Valentyn Chebanov State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Nauky Ave 60, Kharkiv 61072 Ukraine
  • Sergey Desenko State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Nauky Ave 60, Kharkiv 61072 Ukraine

DOI:

https://doi.org/10.17721/fujcV7I1P90-95

Keywords:

multicomponent reactions, heterocycles, 3-aminopyrazole derivative, in water synthesis, microwave-assisted synthesis, ultrasonication

Abstract

Multicomponent reaction of 3-amino-5-methylpyrazole, aliphatic aldehyde (paraformaldehyde or acetaldehyde) and acetylacetone in water by conventional heating, microwave or ultrasound activation undergoes on molar amounts of reagents 2:1:2, respectively, leads bis(2,5,7-trimethylpyrazolo[1,5-a]pyrimidin-6-yl)-substituted methane or to corresponding 1,1-bis-substituted ethane.

References

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Published

2019-07-30

Issue

Vol. 7 No. 1 (2019)

Section

Articles

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